Ayurvedic Supplements To Reduce Liver Toxicity Without Any Side Effects

Liver is an organ which plays important role in keeping body healthy and vital. Any damage and disorder in this organ can lead to severe life threatening conditions. This organ filters blood coming from digestive tract and passes purified blood to rest of the body, makes protein, metabolizes cholesterol, sugar and iron and helps to perform other important functions of body. Any disorder in functions of liver can increase deposition of fat and iron resulting in fatty liver. Those who drink alcohol a lot are at higher risk of liver damage.This organ also secretes bile that helps intestines in absorption of vital nutrients and digestion of food. Liver also stores vitamins that are required for body development. Deficiency of nutrients can also raise disorders in functions of liver which shows symptoms like abdominal pain and inflammation, chronic fatigue, dark urine color, pale colored stool, itchiness in skin, swelling in legs and ankles, nausea, vomiting, loss of appetite, yellowish skin and eye color, etc.

If not treated on time, liver problems can lead to life threatening conditions. One can use Livoxil capsules which are the most effective ayurvedic supplements to reduce liver toxicity. These supplements treat various disorders in liver and promote overall health. Ingredients of these capsules neutralize toxins that come with blood and protect this organ against damage. This organ performs functions normally due to no extra deposition of fat and iron. One is also able to get rid from fatty liver problems. Improvement in liver health promotes bile secretion which improves digestion and metabolism to provide adequate glucose and protein to body to run other body functions. Improvement in functions of this organ can be seen by color of skin, eye and stool which turn from yellow to their normal color. Detoxification and cleansing of liver is done without any disorder in other parts of body.

These ayurvedic supplements to reduce liver toxicity contain Himsara, Kasmard, Pitapada, Guduchi, Bhuamla, Harad, Mandurbhasma, Baranjasif, Kansi, Punarnava, Jhabua, Chitrak, Bukhar-e-mariyam, Amla, Makoy, Kutki, Bang bhasma, Sarpankha, Vaividing and Arjun. All these hers are blended in such a way which not only detoxify liver but also improve health of this organ. These supplements reverse the ill effects of illnesses, diseases and heavy medications on liver health. Powerful ingredients of these capsules promote self-healing property of liver to repair damage as soon as possible. Anti-inflammatory property of these capsules diffuses swelling and gives one relief from pain caused by enlarged liver. These supplements effectively prevent infection in this organ caused by virus, germs or bacteria attack.

These ayurvedic supplements to reduce liver toxicity promote liver functions in spite of all health problems and prohibit problems like hepatitis, cirrhosis, cancer, failure, ascites, gallstones, hemochromatosis, etc. One also gets relief from abnormal weight loss, fatigue, shortness of breath and weakness which happen due to lack of protein for muscle development. Use these ayurvedic supplements for 3 to 4 months in a consistent manner to detoxify liver. Also, keep control over consumption of alcohol to prevent risk of liver damage.

Stem cell-based Gene Therapy Successfully Treats 6 Patients with Rare Hematological Diseases

Chronic granulomatous disease (CGD) is a very rare, life-threatening primary immunodeficiency with the most common type of it being X-linked chronic granulomatous disease (X-CGD), which accounts for 60% – 65% of all types.

Patients with the disease often have a family history, and their parents are mostly married to close relatives. X-CGD mostly affects men, and women are usually carriers of the mutated gene. The main clinical symptom is juvenile onset (mostly within 2 years old, a few can be as late as 10 years old), often manifested by repeated attacks of fatal bacterial or fungal infections, which mainly occur in lymph nodes, subcutaneous tissues, lungs, liver, and gastrointestinal tract. Excessive inflammatory reactions gradually form granulomas, leading to enteritis, obstruction of the genital tract, and chronic wound healing.

X-CGD is caused by a mutation in CYBB gene, leading to difficulty in encoding the gp91phox protein, an important component of the NADPH oxidase complex. And this complex is necessary to respiratory bursts that can effectively kill ingested microorganisms. Due to this kind of mutations, specific white blood cells, including neutrophils, cannot effectively remove bacteria and fungi, so patients are unable to survive severe chronic bacterial and fungal infections.

So, can it be cured? Prophylactic antibiotics and antifungal drugs in current treatment schemes cannot prevent disease progression, and the only curative method at present is allogeneic hematopoietic stem cell transplantation. Although after transplantation from donors compatible with human leukocyte antigen (HLA), the long-term survival rate of patients can reach more than 90%, identifying healthy matched bone marrow donors is difficult, and recovery from transplantation can present complications such as graft-versus-host disease, risk of infection, and transplant rejection.

On January 27, 2020, Donald Kohn‘s team from the University of California, Los Angeles, , published a research paper titled Lentiviral gene therapy for X-linked chronic granulomatous disease in the Nature Medicine.

The study performed stem cell editing therapy on 9 patients with X-CGD. 6 of these patients have now recovered and have been able to stop other antibiotic treatments, which indicates that autologous gene therapy is a very promising treatment for chronic granulomatous disease.

The researchers removed hematopoietic stem cells from patients with X-CGD and modified the cells to correct genetic mutations. The patients’ own genetically modified stem cells were then transplanted back into their own bodies. These stem cells are now capable of producing white blood cells, which in turn produce chemicals that enhance immunity.

“With this gene therapy, you can use the patient’s own stem cells instead of donor cells for transplantation.” Commented by a specialist in Creative Biolabs, a company providing top-notch service for stem cell therapy development, “This means that these cells match the patient perfectly and should be a safer transplant without the risk of immune rejection.”

The 9 patients in the study ranged in age from 2 to 27 years. 4 of them were treated at Great Ormond Street Children’s Hospital in London, and 5 were treated in the United States. In this study, 2 people died of severe infections within three months of receiving treatment because they had severe infections before they received gene therapy. 7 surviving patients were followed up for 12 to 36 months after receiving stem cell-based gene therapy. No new infections associated with chronic granulomatosis have occurred in all, and 6 of 7 have been able to stop prophylactic antibiotics that are commonly used.

Since the publication of the paper, 4 more patients have been treated. All patients are currently free of new infections and complications associated with chronic granulomas.

It is reported that Donald Kohn’s team will work with US and European regulators to conduct larger clinical trials to further study the effectiveness of this innovative therapy. They also plan similar treatments for other types of chronic granulomatous disease caused by leukocyte protein deficiency.

Lenders Club- A Perfect Lending Place to Find Every Credit Facility

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